| Cat. No. |
Product Name |
Information |
| PC-43531 |
Roxadustat
HIF-PHD inhibitor
|
Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM. |
| PC-44597 |
FG-2216
HIF-PHD inhibitor
|
FG-2216 (YM-311, IOX3) is a potent, selective small molecule inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 3.9 nM (PHD2). |
| PC-35269 |
IOX4
PHD2 inhibitor
|
IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases. |
| PC-63449 |
TP0463518
HIF-PHD inhibitor
|
TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively. |
| PC-43267 |
PT2385
HIF-2α inhibitor
|
PT2385 (PT-2385) is a potent, selective, and orally active antagonist of HIF2α, binds to HIF2α PAS-B domain (Kd=50 nM) and disrupts HIF2α/ARNT dimer formation. |
| PC-43241 |
JNJ-42041935
HIF-PHD inhibitor
|
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively. |
| PC-43179 |
ML228
HIF activator
|
ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays. |
| PC-43140 |
Molidustat
HIF-PHD inhibitor
|
Molidustat (BAY 85-3934) is an orally active small molecule inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PHD) with IC50 of 480 nM, 280 nM and 450 nM for PHD1, PHD2, and PHD3, respectively. |
| PC-43087 |
Oltipraz
HIF-1α inhibitor
|
Oltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth, inhibits insulin- or hypoxia-induced HIF-1α expression through an increase in ubiquitination. |
| PC-42847 |
2-Methoxyestradiol
HIF-1 inhibitor, Tubulin inhibitor
|
2-Methoxyestradiol (2ME2, NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro. |
| PC-62894 |
103D5R
HIF-1α inhibitor
|
103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity. |
| PC-62652 |
Chetomin
HIF-1α/p300 inhibitor
|
Chetomin (NSC 289491) is a natural product isolated from Chaetomium species which shows antibacterial and antifungal properties, disrupts the interaction of HIF-1α/p300 at low nanomolar concentrations, strongly increases retinal pigment epithelial cells differentiation. |
