| Cat. No. |
Product Name |
Information |
| PC-43241 |
JNJ-42041935
HIF-PHD inhibitor
|
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively. |
| PC-43179 |
ML228
HIF activator
|
ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays. |
| PC-43140 |
Molidustat
HIF-PHD inhibitor
|
Molidustat (BAY 85-3934) is an orally active small molecule inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PHD) with IC50 of 480 nM, 280 nM and 450 nM for PHD1, PHD2, and PHD3, respectively. |
| PC-43087 |
Oltipraz
HIF-1α inhibitor
|
Oltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth, inhibits insulin- or hypoxia-induced HIF-1α expression through an increase in ubiquitination. |
| PC-42847 |
2-Methoxyestradiol
HIF-1 inhibitor, Tubulin inhibitor
|
2-Methoxyestradiol (2ME2, NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro. |
| PC-62894 |
103D5R
HIF-1α inhibitor
|
103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity. |
| PC-62652 |
Chetomin
HIF-1α/p300 inhibitor
|
Chetomin (NSC 289491) is a natural product isolated from Chaetomium species which shows antibacterial and antifungal properties, disrupts the interaction of HIF-1α/p300 at low nanomolar concentrations, strongly increases retinal pigment epithelial cells differentiation. |
| PC-62483 |
OHM1
HIF-1α inhibitor
|
OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells. |
| PC-62044 |
KHS101
TACC3 inhibitor
|
KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM). |
| PC-61213 |
JNJ-42905343
HIF-PHD inhibitor
|
JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively. |
| PC-70269 |
HIF1-IN-2
HIF-1 inhibitor
|
HIF1-IN-2 is a potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB. |
| PC-60851 |
NOFD
FIH inhibitor
|
NOFD (N-oxalyl-d-phenylalanine) is a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
