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Request The Product List ofHIF/HIF Prolyl-hydroxylase HIF/HIF Prolyl-hydroxylase

Cat. No. Product Name Information
PC-72532

YQ-0629

HIF-2α inhibitor

YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM.
PC-72330

HIF inhibitor 208

HIF inhibitor

HIF inhibitor 208 is a small molecule inhibitor of HIF pathway with IC50 of 0.5 nM.
PC-72329

Arylsulfonamide 64B

HIF inhibitor

Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.
PC-38083

Izilendustat

HIF-PHD inhibitor

Izilendustat is a potent inhibitor of HIF prolyl hydroxylase (PHD) which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2)..
PC-38033

HIF-2α-IN-2

HIF-2α inhibitor

HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor with IC50 of 16 nM in scintillation proximity assay, extracted from patent WO2015035223A1, Compound 232.
PC-35912

KCN1

HIF-1 inhibitor

KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo.
PC-43531

Roxadustat

HIF-PHD inhibitor

Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.
PC-44597

FG-2216

HIF-PHD inhibitor

FG-2216 (YM-311, IOX3) is a potent, selective small molecule inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 3.9 nM (PHD2).
PC-35269

IOX4

PHD2 inhibitor

IOX4 (PHD2 inhibitor IOX4) is a potent, selective inhibitor of prolyl hydroxylase domain enzyme PHD2 with IC50 of 1.6 nM, displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases.
PC-63449

TP0463518

HIF-PHD inhibitor

TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.
PC-43267

PT2385

HIF-2α inhibitor

PT2385 (PT-2385) is a potent, selective, and orally active antagonist of HIF2α, binds to HIF2α PAS-B domain (Kd=50 nM) and disrupts HIF2α/ARNT dimer formation.
PC-43241

JNJ-42041935

HIF-PHD inhibitor

JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively.

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