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You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-YQ-0629
YQ-0629

Chemical Structure : YQ-0629

CAS No.: 1223759-43-0

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YQ-0629 (YQ0629)

Catalog No.: PC-72532Not For Human Use, Lab Use Only.

YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM.
    YQ-0629 could inhibit the expression of HIF-2α with or without the presence of PTX (3 nM) in MCF7 MS culture, does not bind to HIF-1α or affect the expression of HIF-1α.
    YQ-0629 suppresses self-renewal capacity and synergizes with PTX to reverse the chemoresistance of MCF7 MS.
    YQ-0629 inhibits growth of BCSCs derived from breast cancer patients and synergistically increases anti-BCSCs activity of PTX in vivo.

    Physicochemical Properties

    M.Wt 359.429
    Formula C22H21N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((benzyl(furan-2-ylmethyl)amino)methyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

    References

    1. Yan Y, et al. Cell Death Differ. 2022 Mar 17. doi: 10.1038/s41418-022-00963-8.

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