| Cat. No. |
Product Name |
Information |
| PC-23246 |
ZG-2305
FIH inhibitor
|
ZG-2305 is a potent, and selective inhibitor of factor inhibiting HIF (FIH) with Ki of 79.6 nM, 38-fold selectivity over HIF prolyl hydroxylase PHD2. |
| PC-22855 |
DS-1093a
HIF-PHD inhibitor
|
DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells). |
| PC-22692 |
HIF-PH inhibitor DMOG
HIF-PH inhibitor
|
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF prolyl hydroxylase (HIF-PH), induces HIF-1α stabilisation and accmulation in vitro and in vivo. |
| PC-22621 |
N-oxalylglycine
2OG oxygenase inhibitor
|
N-oxalylglycine (NOG) is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.36 uM, 12.3 uM, 11.1 uM and 0.15 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
| PC-22620 |
PHD2 inhibitor BNS
2OG oxygenase inhibitor
|
PHD2 inhibitor BNS is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.3 uM, 0.11 uM, 3.4 uM and 0.25 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
| PC-22619 |
ZG-2291
FIH inhibitor
|
ZG-2291 is a highly potent, selective and in vivo active factor inhibiting HIF (FIH) inhibitor with Ki of 65.3 nM, 39-fold selective over PHD2. |
| PC-22355 |
DS44470011
HIF-PHD inhibitor
|
DS44470011 is a potent, selective hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 1.5 uM for HIF-PHD2, induces erythropoietin (EPO) release in Hep3B cells with EC50 of 8.4 uM. |
| PC-22353 |
PHD inhibitor IOX5
HIF-PHD inhibitor
|
IOX5 is a potent, selective HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 0.15 uM ((PHD2), does not inhibit other 2OG-dependent oxygenases (JMJD6, FIH, KDM6B etc.). |
| PC-22317 |
TC-S7009
HIF2α inhibitor
|
TC-S7009 is a specific inhibitor of HIF-2α with Kd of 81 nM, disrupts HIF-2α′s heterodimerization and DNA-binding activity, reducing the expression of HIF-2α-dependent genes. |
| PC-21729 |
FG-0041
HIF-PH inhibitor
|
FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase. |
| PC-21420 |
MO-2097
hnRNPA2B1 inhibitor
|
MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia. |
