| Cat. No. |
Product Name |
Information |
| PC-42346 |
Vadadustat
HIF-PHD inhibitor
|
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely. |
| PC-42229 |
SYP-5
HIF-1 inhibitor
|
SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis. |
| PC-45387 |
Daprodustat
HIF-PHD inhibitor
|
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively. |
| PC-25242 |
1,4-DPCA
Prolyl-4-hydroxylase inhibitor
|
1,4-DPCA is a potent prolyl-4-hydroxylase (P4H) inhibitor, inhibits collagen hydroxylation in human foreskin fibroblasts with IC50 of 2.4 µM, inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. |
| PC-25040 |
Davotifan
HIF-2α inhibitor
|
Davotifan is a potent, selective HIF-2α inhibitor. |
| PC-24681 |
HIF-1α inhibitor LW6
HIF-1α inhibitor
|
HIF-1α inhibitor LW6 is a specific small compound that inhibits the accumulation of HIF-1α, decreases HIF-1α protein expression without affecting HIF-1β expression, has IC50 of 2.6 uM in HIF-1-mediated cell-based reporter assay in Hep3B cells. |
| PC-24485 |
HIF-PH inhibitor 13
HIF-PH inhibitor
|
HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2). |
| PC-24484 |
M1002
HIF-2 agonist
|
M1002 is a small molecule allosteric agonist of hypoxia-inducible factor-2 (HIF-2) with EC50 of 0.44 uM in luciferase reporter gene assays, enhances the affinity of HIF-2α and ARNT for transcriptional activation. |
| PC-24483 |
ZG-2033
HIF-2α agonist
|
ZG-2033 is a potent, selective and orally bioavailable HIF-2α agonist with EC50 of 490 nM, Emax = 349.2%. |
| PC-24421 |
PRLX 93936
HIF-1α inhibitor
|
PRLX 93936 (PRLX-93936) is a potent small molecule inhibitor of HIF-1α transcriptional factor with IC50 of 0.09 uM, shows with broad antitumor activity in vitro. |
| PC-23636 |
Takeda-17
PHD inhibitor
|
Takeda-17 (PHD-1 inhibitor 17) is a potent, selective inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) with IC50 of 34 nM. |
| PC-23635 |
JPHM-2-167
PHD inhibitor
|
JPHM-2-167 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 1.7, 2.1 and 11 nM for PHD1, PHD2, and PHD3 respectively. |
