| Cat. No. |
Product Name |
Information |
| PC-24655 |
AB521
HIF-2α inhibitor
|
AB521 (Casdatifan) is a potent, allosteric small molecule inhibitor of protumourigenic HIF-2α, potently and selectively inhibits HIF-2α-mediated transcription with IC50 of 28.9 nM in 786-O ccRCC cells (VEGF secretion inhibition). |
| PC-24485 |
HIF-PH inhibitor 13
HIF-PH inhibitor
|
HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2). |
| PC-24484 |
M1002
HIF-2 agonist
|
M1002 is a small molecule allosteric agonist of hypoxia-inducible factor-2 (HIF-2) with EC50 of 0.44 uM in luciferase reporter gene assays, enhances the affinity of HIF-2α and ARNT for transcriptional activation. |
| PC-24483 |
ZG-2033
HIF-2α agonist
|
ZG-2033 is a potent, selective and orally bioavailable HIF-2α agonist with EC50 of 490 nM, Emax = 349.2%. |
| PC-24421 |
PRLX 93936
HIF-1α inhibitor
|
PRLX 93936 (PRLX-93936) is a potent small molecule inhibitor of HIF-1α transcriptional factor with IC50 of 0.09 uM, shows with broad antitumor activity in vitro. |
| PC-23636 |
Takeda-17
PHD inhibitor
|
Takeda-17 (PHD-1 inhibitor 17) is a potent, selective inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) with IC50 of 34 nM. |
| PC-23635 |
JPHM-2-167
PHD inhibitor
|
JPHM-2-167 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 1.7, 2.1 and 11 nM for PHD1, PHD2, and PHD3 respectively. |
| PC-23634 |
DDO-3055
PHD inhibitor
|
DDO-3055 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 64.2 nM toward PHD2, 29- and 2.6-fold selective over PHD1 and PHD3. |
| PC-23246 |
ZG-2305
FIH inhibitor
|
ZG-2305 is a potent, and selective inhibitor of factor inhibiting HIF (FIH) with Ki of 79.6 nM, 38-fold selectivity over HIF prolyl hydroxylase PHD2. |
| PC-22855 |
DS-1093a
HIF-PHD inhibitor
|
DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells). |
| PC-22621 |
N-oxalylglycine
2OG oxygenase inhibitor
|
N-oxalylglycine (NOG) is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.36 uM, 12.3 uM, 11.1 uM and 0.15 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
| PC-22620 |
PHD2 inhibitor BNS
2OG oxygenase inhibitor
|
PHD2 inhibitor BNS is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.3 uM, 0.11 uM, 3.4 uM and 0.25 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
