Catalog No.: PC-45387Not For Human Use, Lab Use Only.
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively.
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively.
Daprodustat (GSK1278863) displays high selectivity over α-KG-dependent iron dioxygenases FIH and CP4H (IC50>9800 nM).
Daprodustat (GSK1278863) stimulate endogenous EPO synthesis and induces effective erythropoiesis by non-EPO effects.
Daprodustat (GSK1278863) shows potential for the treatment of anemia associated with chronic kidney disease.
