HIF-PH inhibitor 13

Chemical Structure : HIF-PH inhibitor 13

Catalog No.: PC-24485Not For Human Use, Lab Use Only.

HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2).

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Biological Activity

HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2).
HIF-PH inhibitor 13 enhances hematopoietic stem cell (HSC) mobilization in combination with G-CSF.
HIF-PH inhibitor 13 is effective at enhancing G-CSF-induced HSC mobilization in mice at a dose of 2 mg/kg.

Physicochemical Properties

M.Wt	379.42
Formula	C20H21N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-cyclohexyl-4-hydroxy-8-oxo-N-(pyridazin-4-ylmethyl)-7,8-dihydro-2,7-naphthyridine-3-carboxamide

References

1. Wu M, et al. J Med Chem. 2025 Mar 6. doi: 10.1021/acs.jmedchem.4c02889.

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