Catalog No.: PC-24484Not For Human Use, Lab Use Only.
M1002 is a small molecule allosteric agonist of hypoxia-inducible factor-2 (HIF-2) with EC50 of 0.44 uM in luciferase reporter gene assays, enhances the affinity of HIF-2α and ARNT for transcriptional activation.
M1002 is a small molecule allosteric agonist of hypoxia-inducible factor-2 (HIF-2) with EC50 of 0.44 uM in luciferase reporter gene assays, enhances the affinity of HIF-2α and ARNT for transcriptional activation. M1002 is capable of altering the conformation of Tyr281 of the HIF-2α PAS-B domain and enhancing the affinity of HIF-2α and ARNT.
