Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-DS-1093a
DS-1093a

Chemical Structure : DS-1093a

CAS No.: 1296273-51-2

Add to Favorites

DS-1093a (DS1093a)

Catalog No.: PC-22855Not For Human Use, Lab Use Only.

DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells).

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells).
DS-1093a (0.3, 1, and 3 mg/kg, oral) showed an increase in hemoglobin (Hgb) levels in rats with adenine-induced renal anemia.
DS-1093ahas a wide safety margin with potent in vitro activity and an optimal pharmacokinetic profile, compared with DS44470011.

Physicochemical Properties

M.Wt 518.61
Formula C29H34N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-(5-hydroxy-2-((1-(4'-(2-hydroxypropyl)-[1,1'-biphenyl]-4-yl)piperidin-4-yl)methyl)-6-methylpyrimidine-4-carbonyl)glycine

References

1. Naoki Tanaka, et al. Bioorg Med Chem Lett. 2024 Jul 15:111:129891.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: