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Chemical Structure : Arylsulfonamide 64B
Catalog No.: PC-72329Not For Human Use, Lab Use Only.
Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.
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Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.
64B inhibited hypoxia-inducible gene expression (c-Met/CXCR4) in Mel290-V6R cells stably expressing an HRE-driven luciferase reporter gene.
64B blocks HIF transcriptional activity by disrupting the interaction between HIF-1α and p300, independently of Factor inhibiting HIF-1 (FIH-1), directly binds to p300 and interferes with p300 recruitment to HIF-1 activated MET and CXCR4 genes.
64B inhibits primary tumor growth, liver metastasis formation, and prolongs survival in orthotopic mice models of uveal melanoma.
| M.Wt | 444.546 | |
| Formula | C23H28N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lei Dong, et al. Clin Cancer Res. 2019 Apr 1;25(7):2206-2218.
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