Catalog No.: PC-72329Not For Human Use, Lab Use Only.
Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.
Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.
64B inhibited hypoxia-inducible gene expression (c-Met/CXCR4) in Mel290-V6R cells stably expressing an HRE-driven luciferase reporter gene.
64B blocks HIF transcriptional activity by disrupting the interaction between HIF-1α and p300, independently of Factor inhibiting HIF-1 (FIH-1), directly binds to p300 and interferes with p300 recruitment to HIF-1 activated MET and CXCR4 genes.
64B inhibits primary tumor growth, liver metastasis formation, and prolongs survival in orthotopic mice models of uveal melanoma.
