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KUSC-5037

Chemical Structure : KUSC-5037

CAS No.: 2789646-66-6

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KUSC-5037 (KUSC5037)

Catalog No.: PC-72705Not For Human Use, Lab Use Only.

KUSC-5037 (KUSC5037) is a novel effective HIF-1 inhibitor with IC50 of 1.2 uM against HIF-1 transcriptional activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KUSC-5037 (KUSC5037) is a novel effective HIF-1 inhibitor with IC50 of 1.2 uM against HIF-1 transcriptional activity.
    KUSC-5037 suppressed the HIF-1α (a regulatory subunit of HIF-1) mRNA, causing decreases in the gene expression of HIF-1 target genes such as carbonic anhydrase 9 (CA9) and vascular endothelial growth factor (VEGF) genes.
    KUSC-5037 directly targets ATP5B protein, a catalytic β subunit of mitochondrial FoF1-ATP synthase.

    Physicochemical Properties

    M.Wt 406.369
    Formula C18H17F3N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((4-propionamido-1H-pyrazol-1-yl)methyl)-N-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxamide

    References

    1. Marina Sakai, et al. Bioorg Med Chem. 2021 Sep 15;46:116375.

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