Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : FG-2216
CAS No.: 223387-75-5
Catalog No.: PC-44597Not For Human Use, Lab Use Only.
FG-2216 (YM-311, IOX3) is a potent, selective small molecule inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 3.9 nM (PHD2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
FG-2216 (YM-311, IOX3) is a potent, selective small molecule inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 3.9 nM (PHD2).
FG-2216 decreases protein expression of DNA/RNA demethylase FTO (in C2C12 cells) and reduces maximal respiration rate in vitro.
FG-2216 up-regulates HIF-1α and increases erythropoietin expression in mice, also significantly reduces bone mineral density and content and alter adipose tissue distribution in mice.
FG-2216 is orally bioavailable and induced significant and reversible Epo induction in vivo.
| M.Wt | 280.66 | |
| Formula | C12H9ClN2O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 31 mg/mL |
|
| Chemical Name/SMILES |
Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]- |
|
1. Hong YR, et al. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7.
2. McMurray F, et al. PLoS One. 2015 Apr 1;10(4):e0121829.
3. Hsieh MM, et al. Blood. 2007 Sep 15;110(6):2140-7.
4. Aik W, et al. Nucleic Acids Res. 2014 Apr;42(7):4741-54.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
