Enarodustat (JTZ-951) | HIF-PHD inhibitor

Chemical Structure : JTZ-951

CAS No.: 1262132-81-9

JTZ-951 (JTZ951, SAL0951, Enarodustat)

Catalog No.: PC-60147Not For Human Use, Lab Use Only.

Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

Packing	Price	Stock
5 mg	$68	In stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$248	In stock
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Biological Activity

Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
Enarodustat (JTZ-951) increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats.

Physicochemical Properties

M.Wt	340.339
Formula	C17H16N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine

References

1. Yosuke Ogoshi, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1320-1325.

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JTZ-951 (JTZ951, SAL0951, Enarodustat)

Biological Activity

Physicochemical Properties

References

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