KC7F2 | HIF-1α inhibitor | Probechem Biochemicals

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Chemical Structure : KC7F2

CAS No.: 927822-86-4

KC7F2 (HIF-1α inhibitor KC7F2)

Catalog No.: PC-45555Not For Human Use, Lab Use Only.

KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM.

Packing	Price	Stock
5 mg (Free Sample)	$28	In stock
50 mg	$158	In stock
100 mg	$258	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM.
KC7F2 prevents the activation of HIF-target genes such as CA IX, MMP2, Endothelin 1, and Enolase 1.
KC7F2 down regulates of HIF-1α protein synthesis by suppression of the phosphorylation of 4EBP1 and p70S6K.

Physicochemical Properties

M.Wt	570.3812
Formula	C16H16Cl4N2O4S4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-

References

1. Narita T, et al. Clin Cancer Res. 2009 Oct 1;15(19):6128-36.

2. Guan G, et al. Cancer Lett. 2015 Feb 1;357(1):254-64.

3. Cammarata PR, et al. Mol Vis. 2015 Sep 1;21:1024-35.

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KC7F2 (HIF-1α inhibitor KC7F2)

Biological Activity

Physicochemical Properties

References

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