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Chemical Structure : MK-8617
CAS No.: 1187990-87-9
Catalog No.: PC-60308Not For Human Use, Lab Use Only.
MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
MK-8617 shows no significant inhibition on the cytochrome p450 enzymes.
MK-8617 exhibits good oral bioavailability, causes increases in circulating reticulocytes in mice and has potential for treatment of anemia.
| M.Wt | 443.45 | |
| Formula | C24H21N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide |
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1. Debenham JS, et al. J Med Chem. 2016 Dec 22;59(24):11039-11049.
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