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MK-8617

Chemical Structure : MK-8617

CAS No.: 1187990-87-9

MK-8617 (MK 8617;MK8617)

Catalog No.: PC-60308Not For Human Use, Lab Use Only.

MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
MK-8617 shows no significant inhibition on the cytochrome p450 enzymes.
MK-8617 exhibits good oral bioavailability, causes increases in circulating reticulocytes in mice and has potential for treatment of anemia.

Physicochemical Properties

M.Wt 443.45
Formula C24H21N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide

References

1. Debenham JS, et al. J Med Chem. 2016 Dec 22;59(24):11039-11049.

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