Enarodustat hydrochloride (JTZ-951) | HIF-PHD inhibitor

Chemical Structure : JTZ-951 hydrochloride

JTZ-951 hydrochloride (JTZ951 hydrochloride, Enarodustat hydrochloride)

Catalog No.: PC-60148Not For Human Use, Lab Use Only.

Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

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Biological Activity

Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
Enarodustat (JTZ-951) increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats.

Physicochemical Properties

M.Wt	376.797
Formula	C17H17ClN4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine hydrochloride

References

1. Yosuke Ogoshi, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1320-1325.

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JTZ-951 hydrochloride (JTZ951 hydrochloride, Enarodustat hydrochloride)

Biological Activity

Physicochemical Properties

References

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