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HIF1-IN-2

Chemical Structure : HIF1-IN-2

CAS No.: 159915-87-4

HIF1-IN-2

Catalog No.: PC-70269Not For Human Use, Lab Use Only.

HIF1-IN-2 is a potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HIF1-IN-2 is a potent, selective HIF-1 inhibitor with IC50 of 1.9 nM, with no signigicant inhibition on HSF and NF-κB.
    HIF1-IN-2 robustly induces PGK1 and Enolase 1 expression, also inhibit endogenous HIF-1 targets.

    Physicochemical Properties

    M.Wt 453.583
    Formula C26H35N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-2-(2-((4-((E)-1-(butoxyimino)propyl)-2,5-dimethylphenoxy)methyl)phenyl)-2-(methoxyimino)-N-methylacetamide

    References

    1. Lin X, et al. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):174-9.

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