NOFD | FIH inhibitor | Probechem Biochemicals

Chemical Structure : NOFD

NOFD (N-oxalyl-d-phenylalanine)

Catalog No.: PC-60851Not For Human Use, Lab Use Only.

NOFD (N-oxalyl-d-phenylalanine) is a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).

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Biological Activity

NOFD (N-oxalyl-d-phenylalanine) is a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).
NOFD also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM).

Physicochemical Properties

M.Wt	237.211
Formula	C11H11NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-oxalyl-d-phenylalanine

References

1. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1.

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NOFD (N-oxalyl-d-phenylalanine)

Biological Activity

Physicochemical Properties

References

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