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DM-NOFD

Chemical Structure : DM-NOFD

CAS No.: 865488-53-5

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DM-NOFD (Dimethyl ester NOFD;N-oxalyl-d-phenylalanine)

Catalog No.: PC-60850Not For Human Use, Lab Use Only.

DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).
    DM-NOFD also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM).
    DM-NOFD is more efficiently reduces HIF1α CAD hydroxylation.

    Physicochemical Properties

    M.Wt 265.265
    Formula C13H15NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Dimethyl N-oxalyl-d-phenylalanine

    References

    1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73.

    2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1.

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