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Chemical Structure : DM-NOFD
Catalog No.: PC-60850Not For Human Use, Lab Use Only.
DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).
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DM-NOFD is the dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).
DM-NOFD also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM).
DM-NOFD is more efficiently reduces HIF1α CAD hydroxylation.
| M.Wt | 265.265 | |
| Formula | C13H15NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73.
2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1.
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