PT2399 | HIF-2α inhibitor | ProbeChem Biochemicals

Chemical Structure : PT2399

CAS No.: 1672662-14-4

PT2399 (PT 2399, PT-2399)

Catalog No.: PC-60317Not For Human Use, Lab Use Only.

PT2399 (PT 2399, PT-2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.

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5 mg	$238	In stock
10 mg	$388	In stock
25 mg	$588	In stock
50 mg	$878	In stock
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Biological Activity

PT2399 (PT 2399, PT-2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.
PT2399 minimally affects a panel of 68 receptors, ion channels, and enzymes.
PT2399 specifically disassembles HIF-2 but not HIF-1 complexes, reduces the expression of HIF-2 target genes (VEGF, SERPINE1, IGFBP3, CCND1, TGFA, and SLC2A1), but not HIF-1 targets (CA9, PGK1, and LDHA).
PT2399 exhibits tumor growth inhibition in selected VHL-deficient clear-cell renal cell carcinoma (ccRCC) models.

Physicochemical Properties

M.Wt	419.32
Formula	C17H10F5NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(1S)-7-(difluoromethylsulfonyl)-2,2-difluoro-1-hydroxy-indan-4-yl]oxy-5-fluoro-benzonitrile

References

1. Chen W, et al. Nature. 2016 Nov 3;539(7627):112-117.

2. Cho H, et al. Nature. 2016 Nov 3;539(7627):107-111.

3. Ricketts CJ, et al. Cancer Cell. 2016 Oct 10;30(4):515-517.

PT2399 (PT 2399, PT-2399)

Biological Activity

Physicochemical Properties

References

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