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Desidustat

Chemical Structure : Desidustat

CAS No.: 1616690-16-4

Desidustat (ZYAN1, ZYAN 1)

Catalog No.: PC-60509Not For Human Use, Lab Use Only.

Desidustat (ZYAN1) is a novel HIF prolyl hydroxylase (PHD) inhibitor under clinical development for the treatment of anemia.

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Biological Activity

Desidustat (ZYAN1) is a novel HIF prolyl hydroxylase (PHD) inhibitor under clinical development for the treatment of anemia.
Desidustat (ZYAN1) increases circulating EPO levels after acute treatment in mice (10.3±3.7 and 40.0±8.5 fold rise at 15 and 30 mg/kg, respectively).
Desidustat (ZYAN1) demonstrates hematinic potential by combined effects on EPO release and efficient iron utilization in nephrectomized rats.

Physicochemical Properties

M.Wt 332.312
Formula C16H16N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[1-(cyclopropylmethoxy)-4-hydroxy-2-oxo- 1,2-dihydroquinoline-3-carbonyl]glycine

References

1. Jain MR, et al. Drug Res (Stuttg). 2016 Feb;66(2):107-12.

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