Catalog No.: PC-43241Not For Human Use, Lab Use Only.
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively.
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively.
JNJ-42041935 shows highly selectivity for PHD relative to FIH (pIC50=4.0).
JNJ-42041935 is approximately equipotent in the HIF-1α accumulation and erythropoietin secretion assays in Hep3B cells as DMOG and 3,4-EDHB.
JNJ-42041935 reverses inflammation-induced anemia at dose of 100 μmol/kg, whereas erythropoietin has no effect.
