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Chemical Structure : KHS101
CAS No.: 1262770-73-9
Catalog No.: PC-62044Not For Human Use, Lab Use Only.
KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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KHS101 (KHS-101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM).
KHS101 works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression.
KHS101 significantly increases neuronal differentiation in rats in vivo.
| M.Wt | 339.46 | |
| Formula | C18H21N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine |
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1. Wurdak H, et al. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7.
2. Guo Y, et al. ACS Chem Biol. 2013 Mar 15;8(3):626-35.
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