Chemical Structure : TP0463518
CAS No.: 1558021-37-6
Catalog No.: PC-63449Not For Human Use, Lab Use Only.
TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.
TP0463518 demonstrates to promote the production of erythropoietin (EPO) following oral administration in mice and rats.
TP0463518 shows potential for treatment of renal anemia.
| M.Wt | 431.829 | |
| Formula | C20H18ClN3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1-((6-(4-chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine |
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1. Hamada M, et al. Bioorg Med Chem Lett. 2018 Apr 16. pii: S0960-894X(18)30351-2.
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