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TP0463518

Chemical Structure : TP0463518

CAS No.: 1558021-37-6

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TP0463518 (TP-0463518, TP 0463518)

Catalog No.: PC-63449Not For Human Use, Lab Use Only.

TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $348 In stock
50 mg $558 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.
TP0463518 demonstrates to promote the production of erythropoietin (EPO) following oral administration in mice and rats.
TP0463518 shows potential for treatment of renal anemia.

Physicochemical Properties

M.Wt 431.829
Formula C20H18ClN3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1-((6-(4-chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine

References

1. Hamada M, et al. Bioorg Med Chem Lett. 2018 Apr 16. pii: S0960-894X(18)30351-2.

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