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Chemical Structure : OHM1
Catalog No.: PC-62483Not For Human Use, Lab Use Only.
OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells.
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OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells。
OHM1 reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals.
| M.Wt | 494.637 | |
| Formula | C24H42N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6.
3. Fang Y, et al. Exp Cell Res. 2007 Mar 10;313(5):867-77.
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