ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays.
ML228 demonstrates to potently activate HIF in vitro as well as its downstream target VEGF (EC50=1.63 uM).
ML228 significantly augmentes VEGFR-2, attenuates Caspase-3 and neuronal apoptosis, and improves neurological Severity Score and tissue edema in the hippocampus of rats, without affecting expression of NF-κB.
