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ML228

Chemical Structure : ML228

CAS No.: 1357171-62-0

ML228 (ML-228;CID-46742353)

Catalog No.: PC-43179Not For Human Use, Lab Use Only.

ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays.

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Biological Activity

ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays.
ML228 demonstrates to potently activate HIF in vitro as well as its downstream target VEGF (EC50=1.63 uM).
ML228 significantly augmentes VEGFR-2, attenuates Caspase-3 and neuronal apoptosis, and improves neurological Severity Score and tissue edema in the hippocampus of rats, without affecting expression of NF-κB.

Physicochemical Properties

M.Wt 415.4891
Formula C27H21N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-

References

1. Theriault JR, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):76-81.

2. Liu XL, et al. Life Sci. 2016 Apr 15;151:243-249.

3. Zhao Y, et al. Sci Rep. 2016 Aug 23;6:31952.

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