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Chemical Structure : ML228
CAS No.: 1357171-62-0
Catalog No.: PC-43179Not For Human Use, Lab Use Only.
ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays.
ML228 demonstrates to potently activate HIF in vitro as well as its downstream target VEGF (EC50=1.63 uM).
ML228 significantly augmentes VEGFR-2, attenuates Caspase-3 and neuronal apoptosis, and improves neurological Severity Score and tissue edema in the hippocampus of rats, without affecting expression of NF-κB.
| M.Wt | 415.4891 | |
| Formula | C27H21N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)- |
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1. Theriault JR, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):76-81.
2. Liu XL, et al. Life Sci. 2016 Apr 15;151:243-249.
3. Zhao Y, et al. Sci Rep. 2016 Aug 23;6:31952.
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