Chetomin | HIF-1α/p300 inhibitor | Probechem Biochemicals

Chemical Structure : Chetomin

CAS No.: 1403-36-7

Chetomin (NSC 289491)

Catalog No.: PC-62652Not For Human Use, Lab Use Only.

Chetomin (NSC 289491) is a natural product isolated from Chaetomium species which shows antibacterial and antifungal properties, disrupts the interaction of HIF-1α/p300 at low nanomolar concentrations, strongly increases retinal pigment epithelial cells differentiation.

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Biological Activity

Chetomin (NSC 289491) is a natural product isolated from Chaetomium species which shows antibacterial and antifungal properties, disrupts the interaction of HIF-1α/p300 at low nanomolar concentrations, strongly increases retinal pigment epithelial cells differentiation.

Physicochemical Properties

M.Wt	710.9
Formula	C31H30N6O6S4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3S,11R,14S)-14-(hydroxymethyl)-3-[3-[[(1S,4S)-4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]octan-1-yl]methyl]indol-1-yl]-18-methyl-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-triene-13,17-dione

References

1. Santos-Aberturas J, et al. Chem Biol. 2015 Oct 22;22(10):1406-14.

2. Kung AL, et al. Cancer Cell. 2004 Jul;6(1):33-43.

3. Maruotti J, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10950-5.

Chetomin (NSC 289491)

Biological Activity

Physicochemical Properties

References

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