ZG-2686 | HIF-2α agonist | Probechem Biochemicals

Chemical Structure : ZG-2686

ZG-2686 (ZG2686)

Catalog No.: PC-26180Not For Human Use, Lab Use Only.

ZG-2686 is a potent HIF-2α agonist with EC50 of 0.25 uM, Emax=375.7%, synergistically enhances HIF-2α-dependent EPO gene expression when combined with prolyl hydroxylase domain (PHD) inhibitor Vadadustat.

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Biological Activity

Physicochemical Properties

M.Wt	317.15
Formula	C13H9BrN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-bromo-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)benzamide

References

1. Yinli Gao, et al. J Med Chem. 2025 Dec 11;68(23):25569-25589.

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ZG-2686 (ZG2686)

Biological Activity

Physicochemical Properties

References

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