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10-NCP

Chemical Structure : 10-NCP

CAS No.: 925681-41-0

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10-NCP (10-DEBC;NCP)

Catalog No.: PC-62208Not For Human Use, Lab Use Only.

10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM).

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    Biological Activity

    10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM).
    10-NCP displays minimal effect on PI3K, PDK1, or SGK1.
    10-NCP blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppresses growth of Rh1, Rh18, and Rh30 cells (IC50=2-5 uM).

    Physicochemical Properties

    M.Wt 381.341
    Formula C20H26Cl2N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

    References

    1. Barmada SJ, et al. Nat Chem Biol. 2014 Aug;10(8):677-85.

    2. Tsvetkov AS, et al. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16982-7.

    3. Thimmaiah KN, et al. J Biol Chem. 2005 Sep 9;280(36):31924-35.

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