| Cat. No. |
Product Name |
Information |
| PC-49529 |
AZD5363
pan-AKT inhibitor
|
Capivasertib (AZD5363) is a potent, selective and orally bioavailable inhibitor of pan-Akt kinases with IC50 of <10 nM. |
| PC-49355 |
ALM301
AKT inhibitor
|
ALM301 (Engasertib) is a potent, selective and allosteric inhibitor of AKT1 and AKT2 with IC50 of 125 nM and 95 nM respectively. |
| PC-49017 |
Ipatasertib
Akt inhibitor
|
Ipatasertib (GDC-0068) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively. |
| PC-38489 |
NSC 177223
Akt inhibitor
|
NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation. |
| PC-38377 |
Vevorisertib trihydrochloride
pan-AKT inhibitor
|
Vevorisertib trihydrochloride (MK-4440, ARQ 751) is a novel potent, selective, allosteric pan-AKT inhibitor with IC50 of 0.55 nM, 0.81 nM and 1.31 nM for AKT1, 2 and 3, respectively. |
| PC-38375 |
Vevorisertib
pan-AKT inhibitor
|
Vevorisertib (MK-4440, ARQ 751) is a novel potent, selective, allosteric pan-AKT inhibitor with IC50 of 0.55 nM, 0.81 nM and 1.31 nM for AKT1, 2 and 3, respectively. |
| PC-73209 |
Miransertib
pan-Akt inhibitor
|
Miransertib (ARQ-092, MK-7075) is a potent, selective and allosteric pan-Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
| PC-73208 |
Miransertib hydrochloride
pan-Akt inhibitor
|
Miransertib (ARQ-092, MK-7075) is a potent, selective and allosteric pan-Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
| PC-38198 |
TAS0612
YBX1 inhibitor
|
TAS0612 (TAS-0612) is an orally bioavailable multikinase inhibitor of AKT, p70S6K, and p90RSK, inhibits Y-box-binding protein (YBX1) phosphorylation. |
| PC-36126 |
Borussertib
Akt inhibitor
|
Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor with IC50 of 0.8 nM and Ki of 2.2 nM for WT Akt. |
| PC-35326 |
Ch-319
Akt inhibitor
|
Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. |
| PC-63553 |
TAS-117 hydrochloride
Akt inhibitor
|
TAS-117 (Pifusertib) hydrochloride is a highly selective, oral, allosteric pan-AKT inhibitor with IC50 of 4.8/1.6/44 nM for Akt1/Akt2/Akt3 respectively. |
