Catalog No.: PC-23915Not For Human Use, Lab Use Only.
AKT1 (E17K) inhibitor compound 3 is a potent, mutant-selective inhibitor of AKT1 (E17K) mutant, potently reduces cell viability of LAPC4-CR cells with EC50 of 20 nM.
AKT1 (E17K) inhibitor compound 3 is a potent, mutant-selective inhibitor of AKT1 (E17K) mutant, potently reduces cell viability of LAPC4-CR cells with EC50 of 20 nM.
compound 3 preferentially forms a reversible imine conjugate with Lys17 in AKT1 (E17K).
Compound 3 shows selectivity for AKT1 (E17K) over AKT2 in terms of both residence time and thermal stabilization.
Compound 3 potently inhibited AKT signalling in E17K-mutant HBCx-2 breast cancer cells.
