AKT1 (E17K) inhibitor compound 3

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Chemical Structure : AKT1 (E17K) inhibitor compound 3

Catalog No.: PC-23915Not For Human Use, Lab Use Only.

AKT1 (E17K) inhibitor compound 3 is a potent, mutant-selective inhibitor of AKT1 (E17K) mutant, potently reduces cell viability of LAPC4-CR cells with EC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AKT1 (E17K) inhibitor compound 3 is a potent, mutant-selective inhibitor of AKT1 (E17K) mutant, potently reduces cell viability of LAPC4-CR cells with EC50 of 20 nM.
compound 3 preferentially forms a reversible imine conjugate with Lys17 in AKT1 (E17K).
Compound 3 shows selectivity for AKT1 (E17K) over AKT2 in terms of both residence time and thermal stabilization.
Compound 3 potently inhibited AKT signalling in E17K-mutant HBCx-2 breast cancer cells.

Physicochemical Properties

M.Wt	540.63
Formula	C33H28N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)amino)ethyl)-2-hydroxybenzaldehyde

References

1. Craven GB, et al. Nature. 2025 Jan;637(8044):205-214.

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