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Chemical Structure : Ipatasertib
CAS No.: 1001264-89-6
Catalog No.: PC-49017Not For Human Use, Lab Use Only.
Ipatasertib (GDC-0068) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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Ipatasertib (GDC-0068, RG7440) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively.
GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models as evidenced by dose-dependent decrease in phosphorylation of downstream targets.
GDC-0068 blocks cell-cycle progression and reduced viability of cancer cell lines.
Oral administration of GDC-0068 resulted in antitumor activity ranging from tumor growth delay to regression in multiple tumor xenograft models.
| M.Wt | 458.003 | |
| Formula | C24H32ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S)-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone |
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1. Blake JF, et al. J Med Chem. 2012 Sep 27;55(18):8110-27.
2. Lin J, et al. Clin Cancer Res. 2013 Apr 1;19(7):1760-72.
3. Zhai B, et al. Mol Cancer Ther. 2014 Jun;13(6):1589-98.
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