Catalog No.: PC-49017Not For Human Use, Lab Use Only.
Ipatasertib (GDC-0068) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively.
Ipatasertib (GDC-0068, RG7440) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively.
GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models as evidenced by dose-dependent decrease in phosphorylation of downstream targets.
GDC-0068 blocks cell-cycle progression and reduced viability of cancer cell lines.
Oral administration of GDC-0068 resulted in antitumor activity ranging from tumor growth delay to regression in multiple tumor xenograft models.
