Chemical Structure : ALTA-2618
CAS No.:
3034255-93-8
ALTA-2618
(Tanerasertib, ALTA2618)
Catalog No.: PC-25099Not For Human Use, Lab Use Only.
Tanerasertib (ALTA-2618) is a potent, highly mutant-selective, allosteric AKT1 E17K inhibitor with EC50 of 7 nM, 22-fold selectivity over WT AKT1 and 140-fold selectivity over WT AKT2.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Tanerasertib (ALTA-2618) is a potent, highly mutant-selective, allosteric AKT1 E17K inhibitor with EC50 of 7 nM, 22-fold selectivity over WT AKT1 and 140-fold selectivity over WT AKT2.
ALTA-2618 demonstrated covalent attachment to the AKT1 E17K protein.
ALTA-2618 induced tumor regressions in AKT1 E17K mutant HR+/HER2low breast cancer, TNBC, and endometrial cancer PDXs at doses as low as 10 mg/kg/d.
Physicochemical Properties
|
M.Wt
|
597.66
|
|
Formula
|
C33H28FN11
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-Pyrimidinecarbonitrile, 4-[[1-[[4-[2-(2-amino-3-pyridinyl)-5-(5-fluoro-2-pyridinyl)-3H-imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-4-piperidinyl]amino]-
|
References
1. Eric A. Murphy, et al. Cancer Res (2024) 84 (7_Supplement): LB173.
2. Patent WO2024073371 A1.
Contact Us
sales@probechem.com
