Chemical Structure : 164A10
CAS No.:
164A10
Catalog No.: PC-23443Not For Human Use, Lab Use Only.
164A10 is a potent Pin1 destabilizer and degrader with IC50 of 4.1 nM in DELFIA displacement assay, destabilizes Pin1 in vitro and also results more effective in causing Pin1 degradation in cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
164A10 is a potent Pin1 destabilizer and degrader with IC50 of 4.1 nM in DELFIA displacement assay, destabilizes Pin1 in vitro and also results more effective in causing Pin1 degradation in cells.
164A10 is very effective in degrading Pin1 in a panel of human cancer cell lines. with DC50 values of ~ 500 nM and Dmax (the maximal level of degradation) close to 100% with all cell lines.
164A10 significantly improved properties over the parent molecule BJP-07-017-3.|
164A10 reduced cell viability in a variety of cancer cell lines.
Physicochemical Properties
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M.Wt
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607.08
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Formula
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C31H32ClFN6O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-((S)-1-amino-3-(5-fluoro-1H-indol-3-yl)-1-oxopropan-2-yl)-1-((S)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)piperidine-2-carboxamide
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References
1. Alboreggia G, et al. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2403330121.
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