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16F16

Chemical Structure : 16F16

CAS No.: 922507-80-0

16F16 (PDI inhibitor 16F16)

Catalog No.: PC-61520Not For Human Use, Lab Use Only.

16F16 is a small molecule protein disulfide isomerase (PDI) inhibitor that suppress apoptosis induced by misfolded proteins.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

16F16 is a small molecule protein disulfide isomerase (PDI) inhibitor that suppress apoptosis induced by misfolded proteins.
16F16 protects rat neurons from cell death triggered by Aβ peptide.
16F16 reduces Zika virus replication in vitro but demonstrates notable toxicity.
16F16 inhibits CHIKV E1-induced cell-cell fusion.

Physicochemical Properties

M.Wt 320.77
Formula C16H17ClN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

References

1. Hoffstrom BG, et al. Nat Chem Biol. 2010 Dec;6(12):900-6.

2. Langsjoen RM, et al. Antiviral Res. 2017 Jul;143:246-251.

3. Goodale LF, et al. Oncotarget. 2017 May 16;8(20):32419-32432.

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