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16F16

Chemical Structure : 16F16

CAS No.: 922507-80-0

16F16 (PDI inhibitor 16F16)

Catalog No.: PC-61520Not For Human Use, Lab Use Only.

16F16 is a small molecule protein disulfide isomerase (PDI) inhibitor that suppress apoptosis induced by misfolded proteins.

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    Biological Activity

    16F16 is a small molecule protein disulfide isomerase (PDI) inhibitor that suppress apoptosis induced by misfolded proteins.
    16F16 protects rat neurons from cell death triggered by Aβ peptide.
    16F16 reduces Zika virus replication in vitro but demonstrates notable toxicity.
    16F16 inhibits CHIKV E1-induced cell-cell fusion.

    Physicochemical Properties

    M.Wt 320.77
    Formula C16H17ClN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

    References

    1. Hoffstrom BG, et al. Nat Chem Biol. 2010 Dec;6(12):900-6.

    2. Langsjoen RM, et al. Antiviral Res. 2017 Jul;143:246-251.

    3. Goodale LF, et al. Oncotarget. 2017 May 16;8(20):32419-32432.

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