17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.
17-AAG induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells.
17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor.
17-AAG inhibits prostate cancer xenografts growth in mice.
Physicochemical Properties
M.Wt
585.6884
Formula
C31H43N3O8
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 55 mg/mL
Chemical Name/SMILES
Geldanamycin, 17-demethoxy-17-(2-propenylamino)-
References
1. Kamal A, et al. Nature. 2003 Sep 25;425(6956):407-10.
2. Solit DB, et al. Clin Cancer Res. 2002 May;8(5):986-93.
3. Nimmanapalli R, et al.Cancer Res. 2001 Mar 1;61(5):1799-804.
