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1ACTA

Chemical Structure : 1ACTA

CAS No.: 2196076-49-8

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1ACTA

Catalog No.: PC-23681Not For Human Use, Lab Use Only.

1ACTA is a specific small molecule inhibitor of IRE1α S-nitrosylation, selectively prevents the NO-induced reduction of RNase activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

1ACTA is a specific small molecule inhibitor of IRE1α S-nitrosylation, selectively prevents the NO-induced reduction of RNase activity.
1ACTA rescues the NO-induced reduction in Xbp1s.
1ACTA does not affect the RNase activity of IRE1α, while suppresses the inhibition of RNase activity by NO.
1ACTA suppresses the decrease in IRE1c cleavage activity caused by S-nitrosoglutathione (GSNO; NO donor) without affecting XBP1 minisubstrate cleavage, and IRE1c cleavage activity.
1ACTA exerts a protective effect against cell death induced by NO and MPP+.

Physicochemical Properties

M.Wt 244.29
Formula C14H16N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-acryloyl-1,2,3,4-tetrahydroquinolin-5-yl)acetamide

References

1. Kurogi H, et al. ACS Chem Biol. 2024 Dec 20;19(12):2429-2437.

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