| Cat. No. |
Product Name |
Information |
| PC-23414 |
IXA6
IRE1/XBP1s activator
|
IXA6 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling. |
| PC-49056 |
KIRA9
IRE1α inhibitor
|
KIRA9 is a potent inhibitor of IRE1α RNase activity with IC50 of 39 nM, blocks ER-localized mRNA decay and apoptosis. |
| PC-49055 |
PAIR1
IRE1α inhibitor
|
PAIR1 is a partial antagonist of IRE1α RNase (PAIR) that fully engage IRE1α's kinase domain (Ki=220 nM) but only partially inhibit its RNase activity. |
| PC-49054 |
PAIR2
IRE1α inhibitor
|
PAIR2 is a partial antagonist of IRE1α RNase (PAIR) that fully engage IRE1α's kinase domain (Ki=8.8 nM) but only partially inhibits its RNase activity. |
| PC-47079 |
KIRA6
IRE1α inhibitor
|
KIRA6 is a potent, ATP-competitive type II IRE1α kinase inhibitor, allosterically inhibits IRE1α RNase kinase activity with IC50 of 0.6 uM and prevents oligomerization. |
| PC-47078 |
B-I09
IRE1 inhibitor
|
B-I09 is a cell permeable IRE-1 RNase inhibitor with IC50 of 1.23 uM, inhibits IRE-1/XBP1 pathway, inhibits growth of human chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. |
| PC-47077 |
D-F07
IRE1 inhibitor
|
D-F07 is a novel fluorescent, covalent IRE-1 inhibitor, potently inhibits XBP-1s expression in MM cells. |
| PC-47076 |
TC-D-F07
IRE1 inhibitor
|
TC-D-F07 is a novel prodrug of the covalent IRE-1 inhibitor D-F07, inhibits IRE-1/XBP-1s pathway in cancer cells. |
| PC-36004 |
KIRA-8
IRE1α inhibitor
|
KIRA-8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM. |
| PC-36003 |
KIRA-7
IRE1α inhibitor
|
KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity. |
| PC-62740 |
MKC9989
IRE1α inhibitor
|
MKC9989 is a specific small molecule inhibitor of IRE1α Rnase (Kd=0.84 uM) with potency against the splicing of XBP1 mRNA (EC50=0.33 uM).. |
| PC-62739 |
MKC8866
IRE1 inhibitor
|
MKC8866 (ORIN1001) is a spectific small molecule inhibitor of mammalian IRE1 RNase activity with IC50 of 0.29 uM. |
