Chemical Structure : IAPD1
CAS No.:
IAPD1
Catalog No.: PC-25598Not For Human Use, Lab Use Only.
IAPD1 is the ester prodrug of IA107 with improved cellular permeability, IA107 is a potent and selective inositol-requiring enzyme 1 alpha (IRE1α) inhibitor, IAPD1 potently inhibits ER stress-induced XBP1 splicing in A549 cells with IC50 of 180 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IAPD1 is the ester prodrug of IA107 with improved cellular permeability, IA107 is a potent and selective inositol-requiring enzyme 1 alpha (IRE1α) inhibitor, IAPD1 potently inhibits ER stress-induced XBP1 splicing in A549 cells with IC50 of 180 nM.
IAPD1 inhibits the XBP1 mRNA splicing with IC50 of 220 nM and 160 nM in HCT 116 cells and HT-29 cells, respectively.
IAPD1 doe not affect the IRE1α protein level.
IAPD1 not show any detectable activity against IRE1α in the FRET assay and LanthaScreen kinase binding assay.
Physicochemical Properties
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M.Wt
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414.30
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Formula
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C21H20BrNO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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ethyl 3-(1-benzoyl-5-bromo-2-methyl-1H-indol-3-yl)propanoate
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References
1. Liu Y, et al. Nat Commun. 2025 Sep 26;16(1):8531.
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