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Chemical Structure : IXA6
CAS No.: 1021106-40-0
Catalog No.: PC-23414Not For Human Use, Lab Use Only.
IXA6 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $178 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
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| 100 mg | Get quote |
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IXA6 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling.
IXA6 moderately increased IRE1-dependent Xbp1 splicing in wild-type mouse embryonic fibroblast (MEF) cells, but not in Ire1-deficient MEF cells.
IXA6 does not significantly activate ATF6 transcriptional signaling and PERK geneset.
IXA6 improves ER proteostasis of destabilized variants of amyloid precursor protein (APP) through an IRE1-dependent mechanism and reduces APP-associated mitochondrial toxicity in cellular models.
| M.Wt | 441.93 | |
| Formula | C22H20ClN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Pyridinesulfonamide, N-[(4-chlorophenyl)methyl]-N-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]- |
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1. Grandjean JMD, et al. Nat Chem Biol. 2020 Oct;16(10):1052-1061.
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