| Cat. No. |
Product Name |
Information |
| PC-45337 |
APY-29
|
APY-29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity. |
| PC-45674 |
4μ8C
IRE1 inhibitor
|
4μ8C (IRE1 Inhibitor III) is a potent IRE1 endonuclease inhibitor, blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation. |
| PC-62740 |
MKC9989
|
MKC9989 is a specific small molecule inhibitor of IRE1α Rnase (Kd=0.84 uM) with potency against the splicing of XBP1 mRNA (EC50=0.33 uM).. |
| PC-62196 |
IRE1α-IN-3
|
IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM. |
| PC-60595 |
GSK2850163
|
A novel potent IRE1α-selective kinase inhibitor that inhibits both the kinase and RNase activities of IRE1α with IC50 of 20 nM and 200 nM, respectively. |
| PC-70079 |
CB5305630
|
CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay. |
| PC-70078 |
NSC95682
|
A potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.41 uM. |
| PC-70077 |
3-Ethoxy-5,6-dibromosalicylaldehyde
|
3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM. |
