| Cat. No. |
Product Name |
Information |
| PC-60595 |
GSK2850163
IRE1α inhibitor
|
GSK2850163 is a potent IRE1α-selective kinase inhibitor that inhibits both the kinase and RNase activities of IRE1α with IC50 of 20 nM and 200 nM, respectively. |
| PC-70079 |
CB5305630
IRE1 inhibitor
|
CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay. |
| PC-70078 |
NSC95682
IRE1 inhibitor
|
NSC95682 is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.41 uM. |
| PC-70077 |
3-Ethoxy-5,6-dibromosalicylaldehyde
IRE1 inhibitor
|
3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM. |
| PC-44755 |
STF-083010
IRE1 inhibitor
|
STF-083010 is a potent and selective IRE1 endoribonuclease inhibitor without affecting IRE1 kinase activity. |
| PC-45675 |
MKC-3946
IRE1α inhibitor
|
MKC-3946 is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells. |
| PC-45337 |
APY29
IRE1α modulator
|
APY-29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity. |
| PC-45674 |
4μ8C
IRE1 inhibitor
|
4μ8C (IRE1 Inhibitor III) is a potent IRE1 endonuclease inhibitor, blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation. |
| PC-22296 |
IRE1α inhibitor 16
IRE1α inhibitor
|
IRE1α inhibitor 18 is a potent, selective and allosteric inhibitor of IRE1α endonuclease activity with enzyme IC50 of 13 nM, cellular IRE1α IC50 of 99 nM in XBP1-Luc cellular assays. |
| PC-22293 |
G-5758
IRE1α inhibitor
|
G-5758 (G5758) is a potent and selective, orally active IRE1α inhibitor with IC50 of 0.27 nM in HTRF IRE1α binding assays, inhibits IRE1α-Rnase with IC50 of 4.3 nM. |
