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GSK2850163

Chemical Structure : GSK2850163

CAS No.: 2121989-91-9

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GSK2850163 (GSK-2850163;GSK 2850163)

Catalog No.: PC-60595Not For Human Use, Lab Use Only.

GSK2850163 is a potent IRE1α-selective kinase inhibitor that inhibits both the kinase and RNase activities of IRE1α with IC50 of 20 nM and 200 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK2850163 is a potent IRE1α-selective kinase inhibitor that inhibits both the kinase and RNase activities of IRE1α with IC50 of 20 nM and 200 nM, respectively.
GSK2850163 binds to pIRE1α and inhibits XBP 1 splicing; only weakly inhibits Ron (IC50= 4.4 uM) and FGFR1 V561M (IC50=17 uM) in a panel of 284 kinases.

Physicochemical Properties

M.Wt 446.41
Formula C24H29Cl2N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(3,4-Dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide

References

1. Concha NO, et al. Mol Pharmacol. 2015 Dec;88(6):1011-23.

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