Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : 4μ8C
CAS No.: 14003-96-4
Catalog No.: PC-45674Not For Human Use, Lab Use Only.
4μ8C (IRE1 Inhibitor III) is a potent IRE1 endonuclease inhibitor, blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
4μ8C (IRE1 Inhibitor III) is a potent IRE1 endonuclease inhibitor, blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.
4μ8C blocks in IL-4, IL-5, and IL-13 production in T cells.
4μ8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in an inducible mutant proinsulin (C96Y) insulinoma cell line.
| M.Wt | 204.1788 | |
| Formula | C11H8O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 27 mg/mL |
|
| Chemical Name/SMILES |
2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo- |
|
1. Cross BC, et al. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78.
2. Kemp KL, et al. J Biol Chem. 2013 Nov 15;288(46):33272-82.
3. Zhang L, et al. BMC Cell Biol. 2014 Jul 10;15:29.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
