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Chemical Structure : 3-Ethoxy-5,6-dibromosalicylaldehyde
Catalog No.: PC-70077Not For Human Use, Lab Use Only.
3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM.
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3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM.
3-Ethoxy-5,6-dibromosalicylaldehyde binds to IRE1 in a specific, reversible and dose-dependent manner and inhibits XBP-1 splicing induced pharmacologically in human cells.
3-Ethoxy-5,6-dibromosalicylaldehyde shows no inhibitory activity for RNases A, T1, or L.
| M.Wt | 323.97 | |
| Formula | C9H8Br2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Volkmann K, et al. J Biol Chem. 2011 Apr 8;286(14):12743-55.
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