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3-Ethoxy-5,6-dibromosalicylaldehyde

Chemical Structure : 3-Ethoxy-5,6-dibromosalicylaldehyde

CAS No.: 20041-64-9

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3-Ethoxy-5,6-dibromosalicylaldehyde (IRE1 inhibitor)

Catalog No.: PC-70077Not For Human Use, Lab Use Only.

3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM.
    3-Ethoxy-5,6-dibromosalicylaldehyde binds to IRE1 in a specific, reversible and dose-dependent manner and inhibits XBP-1 splicing induced pharmacologically in human cells.
    3-Ethoxy-5,6-dibromosalicylaldehyde shows no inhibitory activity for RNases A, T1, or L.

    Physicochemical Properties

    M.Wt 323.97
    Formula C9H8Br2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,3-dibromo-5-ethoxy-6-hydroxybenzaldehyde

    References

    1. Volkmann K, et al. J Biol Chem. 2011 Apr 8;286(14):12743-55.

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