IRE1α-IN-3 |CAS:1414938-21-8 Probechem Biochemicals

Chemical Structure : IRE1α-IN-3

IRE1α-IN-3

Catalog No.: PC-62196Not For Human Use, Lab Use Only.

IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM.

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Biological Activity

IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM.
IRE1α-IN-3 demonstrates dose-dependent reduction of IRE1α kinase autophosphorylation amd inhibition of XBP1 RNA cleavage in the WT cell lines.

Physicochemical Properties

M.Wt	504.517
Formula	C27H23F3N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(8-amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea

References

1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9.

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IRE1α-IN-3

Biological Activity

Physicochemical Properties

References

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