NSC95682 | IRE1 inhibitor | Probechem Biochemicals

Chemical Structure : NSC95682

CAS No.: 20035-41-0

NSC95682 (3-Methoxy-6-bromosalicylaldehyde)

Catalog No.: PC-70078Not For Human Use, Lab Use Only.

NSC95682 is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.41 uM.

Packing	Price	Stock
10 mg (Free Sample)	$28	In stock
100 mg	$68	In stock
250 mg	$118	In stock
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Biological Activity

NSC95682 is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.41 uM.
NSC95682 binds to IRE1 in a specific, reversible and dose-dependent manner and inhibits XBP-1 splicing induced pharmacologically in human cells.
NSC95682 inhibits XBP-1 splicing in vivo model of acute ER stress.

Physicochemical Properties

M.Wt	231.045
Formula	C8H7BrO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Methoxy-6-bromosalicylaldehyde

References

1. Volkmann K, et al. J Biol Chem. 2011 Apr 8;286(14):12743-55.

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NSC95682 (3-Methoxy-6-bromosalicylaldehyde)

Biological Activity

Physicochemical Properties

References

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