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Chemical Structure : MKC-3946
CAS No.: 1093119-54-0
Catalog No.: PC-45675Not For Human Use, Lab Use Only.
MKC-3946 is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MKC-3946 is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells.
MKC-3946 enhances cytotoxicity of ER stressors; in vivo active in mice model of ER stress.
| M.Wt | 380.4601 | |
| Formula | C21H20N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (3.8 mg/mL) |
|
| Chemical Name/SMILES |
1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]- |
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1. Mimura N, et al. Blood. 2012 Jun 14;119(24):5772-81.
2. Zhang L, et al. BMC Cell Biol. 2014 Jul 10;15:29.
3. Sun H, et al. Oncotarget. 2016 Apr 5;7(14):18736-49.
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