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MKC-3946

Chemical Structure : MKC-3946

CAS No.: 1093119-54-0

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MKC-3946 (MKC3946;MKC 3946)

Catalog No.: PC-45675Not For Human Use, Lab Use Only.

MKC-3946 is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MKC-3946 is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells.
MKC-3946 enhances cytotoxicity of ER stressors; in vivo active in mice model of ER stress.

Physicochemical Properties

M.Wt 380.4601
Formula C21H20N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO (3.8 mg/mL)
Chemical Name/SMILES

1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-

References

1. Mimura N, et al. Blood. 2012 Jun 14;119(24):5772-81.

2. Zhang L, et al. BMC Cell Biol. 2014 Jul 10;15:29.

3. Sun H, et al. Oncotarget. 2016 Apr 5;7(14):18736-49.

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