CB5305630 | IRE1 inhibitor | Probechem Biochemicals

Chemical Structure : CB5305630

CB5305630 (CB-5305630, CB 5305630)

Catalog No.: PC-70079Not For Human Use, Lab Use Only.

CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay.

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Biological Activity

CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay.
CB5305630 also inhibits the cleavage of a radiolabeled Xbp1-derived RNA probe in vitro.

Physicochemical Properties

M.Wt	280.278
Formula	C16H12N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-7-hydroxy-4-methyl-8-((pyridin-2-ylimino)methyl)-2H-chromen-2-one

References

1. Cross BC, et al. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78.

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CB5305630 (CB-5305630, CB 5305630)

Biological Activity

Physicochemical Properties

References

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