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Chemical Structure : APY29
CAS No.: 1216665-49-4
Catalog No.: PC-45337Not For Human Use, Lab Use Only.
APY-29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $58 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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APY29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.
APY29 divergently affects IRE1α oligomerization, demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α.
| M.Wt | 332.3625 | |
| Formula | C17H16N8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mg/mL |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)- |
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1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9.
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