APY29 | IRE1 inhibitor | Probechem Biochemicals

Chemical Structure : APY29

CAS No.: 1216665-49-4

APY29 (IRE1α inhibitor APY29, APY-29)

Catalog No.: PC-45337Not For Human Use, Lab Use Only.

APY-29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.

Packing	Price	Stock
5 mg	$58	In stock
10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$238	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

APY29 is an allosteric modulator of IRE1α that inhibits IRE1α autophosphorylation with IC50 of 280 nM and activates IRE1α RNase activity.
APY29 divergently affects IRE1α oligomerization, demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α.

Physicochemical Properties

M.Wt	332.3625
Formula	C17H16N8
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 10 mg/mL
Chemical Name/SMILES	2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-

References

1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

APY29 (IRE1α inhibitor APY29, APY-29)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.