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STF-083010

Chemical Structure : STF-083010

CAS No.: 307543-71-1

STF-083010 (STF083010)

Catalog No.: PC-44755Not For Human Use, Lab Use Only.

STF-083010 is a potent and selective IRE1 endoribonuclease inhibitor without affecting IRE1 kinase activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

STF-083010 is a potent and selective IRE1 endoribonuclease inhibitor without affecting IRE1 kinase activity.
STF-083010  shows significant antimyeloma activity in model human MM xenografts.

Physicochemical Properties

M.Wt 317.3828
Formula C15H11NO3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Thiophenesulfonamide, N-[(2-hydroxy-1-naphthalenyl)methylene]-

References

1. Papandreou I, et al. Blood. 2011 Jan 27;117(4):1311-4.

2. Chien W, et al. Oncotarget. 2014 Jul 15;5(13):4881-94.

3. Sun H, et al. Oncotarget. 2016 Apr 5;7(14):18736-49.

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