B-I09 | IRE1 inhibitor | Probechem Biochemicals

Chemical Structure : B-I09

CAS No.: 1607803-67-7

B-I09 (B I09, BI 09)

Catalog No.: PC-47078Not For Human Use, Lab Use Only.

B-I09 is a cell permeable IRE-1 RNase inhibitor with IC50 of 1.23 uM, inhibits IRE-1/XBP1 pathway, inhibits growth of human chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$188	In stock
25 mg	$298	In stock
50 mg	$458	In stock
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Biological Activity

B-I09 is a cell permeable IRE-1 RNase inhibitor with IC50 of 1.23 uM, inhibits IRE-1/XBP1 pathway, inhibits growth of human chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo.

Physicochemical Properties

M.Wt	303.31
Formula	C16H17NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one

References

1. Chih-Hang Anthony Tang, et al. J Clin Invest. 2014 Jun;124(6):2585-98.

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B-I09 (B I09, BI 09)

Biological Activity

Physicochemical Properties

References

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