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B-I09

Chemical Structure : B-I09

CAS No.: 1607803-67-7

B-I09 (B-I 09)

Catalog No.: PC-47078Not For Human Use, Lab Use Only.

B-I09 is a cell permeable IRE-1 RNase inhibitor with IC50 of 1.23 uM, inhibits IRE-1/XBP1 pathway, inhibits growth of human chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

B-I09 is a cell permeable IRE-1 RNase inhibitor with IC50 of 1.23 uM, inhibits IRE-1/XBP1 pathway, inhibits growth of human chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo.

Physicochemical Properties

M.Wt 303.31
Formula C16H17NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one

References

1. Chih-Hang Anthony Tang, et al. J Clin Invest. 2014 Jun;124(6):2585-98.

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