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1V209

Chemical Structure : 1V209

CAS No.: 1062444-54-5

1V209 (TLR7 agonist 1V209)

Catalog No.: PC-73063Not For Human Use, Lab Use Only.

1V209 is a synthetic small molecule TLR7 specific ligand and agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

1V209 is a synthetic small molecule TLR7 specific ligand and agonist.
1V209 can be stably conjugated to primary amine functionalized Ficoll or dextran using benzoic acid functional groups.
1V209 conjugated to silica nanoshells is capable of activating an inflammasome pathway to enhance both innate immune-stimulatory and adjuvant potencies of the TLR7 agonist, thereby broadening applications of innate immune stimulators.

Physicochemical Properties

M.Wt 359.342
Formula C16H17N5O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)benzoic acid

References

1. Shinchi H, et al. Bioconjug Chem. 2015 Aug 19;26(8):1713-23.

2. Huang CH, et al. ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26637-26647.

3. Baba A, et al. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126840.

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