1V209 is a synthetic small molecule TLR7 specific ligand and agonist.
1V209 can be stably conjugated to primary amine functionalized Ficoll or dextran using benzoic acid functional groups.
1V209 conjugated to silica nanoshells is capable of activating an inflammasome pathway to enhance both innate immune-stimulatory and adjuvant potencies of the TLR7 agonist, thereby broadening applications of innate immune stimulators.
